Scientific section: MYELOID NEOPLASIA; HEMATOPOIESIS AND STEM CELLS Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts Short title: GENETIC ANOMALIES IN MSCs OF MDS/AML PATIENTS
نویسندگان
چکیده
Department of Hematology and Oncology, Charité University School of Medicine, Berlin, Germany; Department of Hematology and Oncology, University Hospital, Mannheim, Germany; Genetics Laboratory and Out-Patients’ Clinic, Berlin, Germany; Institute of Medical Genetic, Charité University School of Medicine, Berlin, Germany Corresponding Author: Olga Blau, MD, PhD Department of Hematology and Oncology, Charité University School of Medicine, Hindenburgdamm 30, D-12200 Berlin, Germany Tel: 0049-30-8445-2648 Fax: 0049-30-8445-4468 Email: [email protected] Blood First Edition Paper, prepublished online September 23, 2011; DOI 10.1182/blood-2011-03-343467
منابع مشابه
Mesenchymal stromal cells in myeloid malignancies
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal myeloid disorders characterized by hematopoietic insufficiency. As MDS and AML are considered to originate from genetic and molecular defects of hematopoietic stem and progenitor cells (HSPC), the main focus of research in this field has focused on the characterization of these cells. Recently, the contribution of BM mi...
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Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, including mesenchymal stem cells (MSCs) and their progeny, play a pivotal role in the evolution an...
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The morphologic dysplasia manifested in any lineage(s) frequently does not correlate with the specific cytopenia(s) in individual MDS cases. For this reason, WHO revision for adult MDS classification in 2016 removes terms such as “refractory anemia” and “refractory cytopenia” and replaces them with “myelodysplastic syndrome” followed by the appropriate modifiers: single vs multilineage dysplasi...
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UNLABELLED BACKGROUND Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myel...
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Bone marrow (BM) mesenchymal stem/stromal cells (MSCs) are vital in hematopoiesis. Whether BM-MSCs alter their characteristics in Myelodysplastic Syndromes (MDS) is still controversial. We characterized MSCs of de novo MDS patients in Sri Lanka who have not been reported previously in the literature. We also analyzed MSCs derived from different MDS subtypes. MSCs were culture-expanded, characte...
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